In 1995, only three model trims were left in the Isuzu Pickup lineup, the S Short Bed, the S Long Bed and the S Spacecab. No changes were made in all three model trims. The S Spacecab is powered with 2.6-liter 4-cylinder engine with 120-horsepower at 4600-rpm and 146-foot-pound of torque at 2600-rpm. A 2.3-liter 4-cylinder engine powers the S Short Bed and the S Long Bed. It delivers 96-horsepower and 128-foot-pound of torque.

5-speed manual overdrive is standard in all three. Air conditioning system and cassette player are available as an option in all 1995 Isuzu Pickup model trims. ABS brakes are standard. Maximum seating is 3. Airbags and traction control are not available. Consumer reviews rated the 1995 Isuzu Pickup 6.6 in styling, 7 in performance, 10 in reliability, 6 in seat comfort, 6.5 in interior, 7.7 in quality, 7.3 in recommendation, and an overall rating of 7.1. The 1995 Isuzu Pickup is the last among the Isuzu pickup models. Isuzu ceased its production in 1996.